You hate to drive screws into end grain because they can pull right out. But sometimes, you can't avoid driving them into the end of a board, such as in the case of the bed hardware shown above.

For a strong joint, give the screw some face grain to dig into. Here's how: Drill a dowel-diameter hole through the face of the project part, located so that the screw threads will fall mostly or completely inside the hole. Then, glue a length of dowel into the hole. Set the dowels so their end grain is perpendicular to the grain on the face of the project part. Cut the ends flush with your project part. Now, drill your pilot holes and drive in the screws.
—Tom E. Moore, Madison, Va.